Penerapan Aksesibilitas pada Desain Fasilitas Pendidikan Sekolah Luar Biasa

Pada dasarnya setiap sekolah memiliki fasilitas pendidikan yang kebutuhannya disesuaikan dengan aktivitas ataupun kurikulum yang ada di dalamnya. Tidak beda dengan Sekolah Luar Biasa yang memiliki Fasilitas Pendidikan khusus bagi anak – anaknya. Selain kurikulum dan pembelajarannya yang berbeda, desain ruang kelas sampai kamar mandi pun memiliki kekhususan dalam penempatannya. Desain ruang kelas tidak hanya berkutat pada bagaimana ruang kelas tersebut mampu menciptakan suasana yang kondusif, tetapi melihat dari kekhususan anak – anak tersebut maka perlu diciptakannya suasana yang komunikatif, nyaman, aman, dan edukatif. Oleh karena itu perlu adanya penerapan aksesibilitas secara khusus pada desain fasilitas pendidikan yang ada utamanya untuk Sekolah Luar Bias

MAIN ECONOMIC, POLITICAL AND SOCIAL CONSEQUENCES OF THE EUROPEAN CRISIS IN PERIPHERAL COUNTRIES

The European crisis has triggered a series of economic, political and social consequences in the European Union, particularly for the euro zone member states and this has generated a public discussion about the pertinence of a single currency. This paper presents some of the social, political and economic consequences. One of the main consequences of the crisis in peripheral countries is higher unemployment. The political reconfiguration at the national-level in some European countries is presented. The pressures on labor markets are high and there is a reconfiguration in the immigration and emigration in Europe

Topological Tumor Graphs: A Graph-Based Spatial Model to Infer Stromal Recruitment for Immunosuppression in Melanoma Histology.

Despite the advent of immunotherapy, metastatic melanoma represents an aggressive tumor type with a poor survival outcome. The successful application of immunotherapy requires in-depth understanding of the biological basis and immunosuppressive mechanisms within the tumor microenvironment. In this study, we conducted spatially explicit analyses of the stromal-immune interface across 400 melanoma hematoxylin and eosin (H&E) specimens from The Cancer Genome Atlas. A computational pathology pipeline (CRImage) was used to classify cells in the H&E specimen into stromal, immune, or cancer cells. The estimated proportions of these cell types were validated by independent measures of tumor purity, pathologists' estimate of lymphocyte density, imputed immune cell subtypes, and pathway analyses. Spatial interactions between these cell types were computed using a graph-based algorithm (topological tumor graphs, TTG). This approach identified two stromal features, namely stromal clustering and stromal barrier, which represented the melanoma stromal microenvironment. Tumors with increased stromal clustering and barrier were associated with reduced intratumoral lymphocyte distribution and poor overall survival independent of existing prognostic factors. To explore the genomic basis of these TTG-derived stromal phenotypes, we used a deep learning approach integrating genomic (copy number) and transcriptomic data, thereby inferring a compressed representation of copy number-driven alterations in gene expression. This integrative analysis revealed that tumors with high stromal clustering and barrier had reduced expression of pathways involved in naïve CD4 signaling, MAPK, and PI3K signaling. Taken together, our findings support the immunosuppressive role of stromal cells and T-cell exclusion within the vicinity of melanoma cells. SIGNIFICANCE: Computational histology-based stromal phenotypes within the tumor microenvironment are significantly associated with prognosis and immune exclusion in melanoma

Outside- in single-lasso loop technique for meniscal repair: Fast, economic, and reproducible

The current understanding of the biomechanical role of the meniscus, in conjunction with the increasing efforts to achieve its preservation within the orthopaedic community during treatment of meniscal lesions, has prompted the development of different meniscal repair techniques. The outside-in technique is recommended for anterior horn and middle-segment meniscal tears and has been recognized as a low-cost procedure with a low incidence of complications. Diverse modifications of this technique have been published over the past decade. On the basis of these previous outside-in technique modifications and aiming to simplify and reduce the number of surgical steps, as well as simplify suture and/or instrument manipulation, during this technique, we describe the single–lasso loop outside-in technique for meniscal repair. We believe this modified technique represents a simplified, economic, and highly reproducible procedure option whenever an outside-in technique for meniscal repair is considered

Experiencias en el uso de guías de actividades de aprendizaje

Las guías de actividades de aprendizaje muestran todas las tareas que cada estudiante tiene que realizar para conseguir los objetivos educativos en una determinada asignatura. En este trabajo se analizan los resultados de su uso a lo largo de tres cursos académicos: El alumnado está satisfecho con la presentación de la información pero aún quedan muchas posibilidades para potenciar estas guías como herramienta educativa.Este trabajo ha sido realizado en el marco del proyecto para la mejora de la calidad docente MQD2008-114 (“Guía virtual de aprendizaje de Fundamentos de computadores a través de fichas de actividades”), financiado por la AGAUR de la Generalitat de Catalunya

Centralised and Distributed Optimization for Aggregated Flexibility Services Provision

The recent deployment of distributed battery units in prosumer premises offer new opportunities for providing aggregated flexibility services to both distribution system operators and balance responsible parties. The optimization problem presented in this paper is formulated with an objective of cost minimization which includes energy and battery degradation cost to provide flexibility services. A decomposed solution approach with the alternating direction method of multipliers (ADMM) is used instead of commonly adopted centralised optimization to reduce the computational burden and time, and then reduce scalability limitations. In this work we apply a modified version of ADMM that includes two new features with respect to the original algorithm: first, the primal variables are updated concurrently, which reduces significantly the computational cost when we have a large number of involved prosumers; second, it includes a regularization term named Proximal Jacobian (PJ) that ensures the stability of the solution. A case study is presented for optimal battery operation of 100 prosumer sites with real-life data. The proposed method finds a solution which is equivalent to the centralised optimization problem and is computed between 5 and 12 times faster. Thus, aggregators or large-scale energy communities can use this scalable algorithm to provide flexibility services.Comment: 10 pages, 7 figure

T-cell receptor determinants of response to chemoradiation in locally-advanced HPV16-driven malignancies

BackgroundThe effect of chemoradiation on the anti-cancer immune response is being increasingly acknowledged; however, its clinical implications in treatment responses are yet to be fully understood. Human papillomavirus (HPV)-driven malignancies express viral oncogenic proteins which may serve as tumor-specific antigens and represent ideal candidates for monitoring the peripheral T-cell receptor (TCR) changes secondary to chemoradiotherapy (CRT).MethodsWe performed intra-tumoral and pre- and post-treatment peripheral TCR sequencing in a cohort of patients with locally-advanced HPV16-positive cancers treated with CRT. An in silico computational pipeline was used to cluster TCR repertoire based on epitope-specificity and to predict affinity between these clusters and HPV16-derived epitopes.ResultsIntra-tumoral repertoire diversity, intra-tumoral and post-treatment peripheral CDR3β similarity clustering were predictive of response. In responders, CRT triggered an increase peripheral TCR clonality and clonal relatedness. Post-treatment expansion of baseline peripheral dominant TCRs was associated with response. Responders showed more baseline clustered structures of TCRs maintained post-treatment and displayed significantly more maintained clustered structures. When applying clustering by TCR-specificity methods, responders displayed a higher proportion of intra-tumoral TCRs predicted to recognise HPV16 peptides.ConclusionsBaseline TCR characteristics and changes in the peripheral T-cell clones triggered by CRT are associated with treatment outcome. Maintenance and boosting of pre-existing clonotypes are key elements of an effective anti-cancer immune response driven by CRT, supporting a paradigm in which the immune system plays a central role in the success of CRT in current standard-of-care protocols

Detection of SARS-CoV-2 RNA by PCR in a series of corpses sent for autopsy

A partir de la aparición del SARS-CoV-2 en el mundo se desató la pandemia de COVID-19 que afectó a 185 países aparecieron numerosas publicaciones científicas presentando datos epidemiológicos, clínicos, estadísticos y microbiológicos. La elevada mortalidad ha implicado la necesidad de contar con datos cada vez más precisos en relación al virus y a su comportamiento en el medio y, por otro lado, enfrentó a los equipos de salud con un grave problema en relación al manejo seguro de cadáveres y a los riesgos de transmisión viral que ello implica. El objetivo del presente estudio ha sido detectar la presencia de ARN del SARS-CoV-2 en cadáveres remitidos a la Morgue Judicial que no estuvieran comprendidos en la definición de caso sospechoso propuesta por el Ministerio de Salud de la República Argentina. De un total de 153 cadáveres ingresados entre el 16 y el 24 de abril del 2020 en la Morgue Judicial se realizaron hisopados nasofaríngeos y orofaríngeos en 50 cadáveres elegidos basándose en criterios de inclusión previamente establecidos para efectuar una detección de ARN viral mediante técnica RT PCR. De todos éstos, a 2 de los cadáveres (4%) se les detectó ARN viral, los mismos no estaban clasificados como casos sospechosos de COVID-19. En el caso de 28 cadáveres remitidos como casos sospechosos de COVID-19, en el mismo período, se observó una prevalencia similar, 3,6%.Following the emergence of SARS-CoV-2 in the world, the COVID-19 pandemic broke out, affecting 185 countries. There have been numerous scientific publications presenting epidemiological, clinical, statistical, and microbiological data. The high mortality has implied the need for increasingly accurate data regarding the virus and its behaviour in the environment and, on the other hand, faced health teams with a serious problem in relation to the safe handling of corpses and the risks of transmission that this implies. The objective of this study was to detect the presence of SARS-CoV-2 RNA in corpses sent to the National Judicial Morgue that were not included in the definition of a suspected case submitted by the Argentine Ministry of Health. Nasopharyngeal and oropharyngeal swabs were taken from 101 cadavers chosen randomly and based on inclusion criteria for detection of viral RNA using the RT-PCR technique. Of the cadavers included in the study, 16.8%, not classified as suspected cases of COVID-19, were tested for the presence of viral RNA in the samples collected.Fil: D'Addario, Adriana Claudia. Morgue Judicial de la Nación; ArgentinaFil: Bustos, Cristina A.. Morgue Judicial de la Nación; ArgentinaFil: Cohen, Roberto V.. Morgue Judicial de la Nación; ArgentinaFil: Rullan Corna, Alejandro Félix. Morgue Judicial de la Nación; ArgentinaFil: Gómez, Patricia Elizabeth. Morgue Judicial de la Nación; ArgentinaFil: Torrisi, Rubén H.. Morgue Judicial de la Nación; ArgentinaFil: Di Salvo, Héctor. Morgue Judicial de la Nación; ArgentinaFil: Herbstein, Jorge A.. Morgue Judicial de la Nación; ArgentinaFil: Remes Lenicov, Federico. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Maffia Bizzozero, Santiago. Morgue Judicial de la Nación; Argentin